Isocycloseram: Novel Model Of Action and Broad Spectrum Of Activity Against Urban Pests And Public Health Disease Vectors

Our studies demonstrated that isocycloseram was active at low doses against the German cockroach, Blattella germanica (L.) [median lethal dose (LD₅₀) 5–15 ng per insect at 72 h, topical assays]; common bed bug (Cimex lectularius (L.) (approximately 40 mg m², residual surface spray); and mosquito, Anopheles stephensi Liston (120 and 150 mg m² treated surfaces, aged indoors for 9 months). Additionally, cockroach gel bait at 1% isocycloseram (w/w) caused 95–100% mortality in German, American (Periplaneta americana (L.), and oriental (Blatta orientalis (L.) cockroaches within 5–14 days. Given its non-repellent nature, delayed effects, and activity at low rates, isocycloseram can be a very effective compound against subsocial, social, and other human disease vector insect pests.