Mus Musculus Domesticus Carrying Vkorc1Spr And Susceptibility To Rodenticides

Abstract:
This paper describes the control of a mice infestation of a bakery in Lyon (France). Where other anticoagulant molecules used for the treatment of the situation failed, the use of difethialone grain showed a great efficacy in the control of this population. Live mice captured on the site where genetically tested and appeared to be M. musculus domesticus species with a M. spretus Vkorc1 gene naturally introgressed. Susceptibility to AVKs of VKORC1spr was in vitro evaluated by expressing recombinant enzymes in yeasts. The use of this in vitro yeast system is of great interest for monitoring the anticoagulant activity of VKORC1 in AVK resistant rodents and for the development and the evaluation of new anticoagulants molecules.